Comparison of Healing Effect Between Fibrin Gel Complex Bone Morphological Protein and Reconstituted Bone Xenograft After Reconstruction of Sports Ligament Injury

Abstract

To study the effect of fibrin gel complex bone morphological protein (FG-BMP) and RBX on the healing of tendon-bone interface. 51 live rabbits were selected, and 51 rabbits were randomly divided into 3 groups: FG-BMP, RBX and control groups. Bilateral ACL reconstruction was performed in 51 rabbits, with different biomaterials injected at the tendon-bone interface, and none applied in the FG-BMP, RBX, and control groups. Material extraction, imaging examination, histological analysis, and biomechanical tests were conducted at 2 weeks after surgery, 6 weeks later, and 12 weeks after surgery, respectively. The tendon-interbone growth rate of rabbits using FG-BMP biomaterials and RBX biomaterials was significantly improved in the FG-BMP and RBX groups compared with the control group (P < 0.05). Histological results showed that all rabbits in the RBX group were surrounded by newborn bone tissue around the tendon-bone transplantation tendon and had a significantly greater number of newborn bone tissue than in the FG-BMP group (P < 0.05). The biomechanical test results showed that the two groups of FG-BMP biomaterials improved the maximum tension compared with the control group (P < 0.05), where the RBX tension, the difference was significant (P < 0.05), and the FG-BMP group although higher than the control group (P > 0.05). Conclusion: In the comparison of promoting tendon-bone interface healing, FG-BMP biomaterials and RBX biomaterials have significant results, especially RBX materials have obvious advantages in accelerating tendon-bone interface healing.