Abstract
Propofol decreases systemic blood pressure. This is accompanied by corresponding changes in cardiac output and systemic vascular resistance. Systemic blood pressure reductions of 50% have been seen with 2mg/kg bolus of propofol. A negative inotropic effect of propofol may be due to decrease in intracellular calcium availability secondary to inhibition of transsarcolemmal calcium influx. Base line heart rate, blood pressure, SpO2, Respiratory rate and Entropy values was recorded. Patients were randomly allocated into two groups of 70 each using sealed envelope technique. In our study we have found that suppression of intubation response was better with fentanyl 2mcg/kg than butorphanol 20mcg/kg which is statistically significant.
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