Comparison of effects of irbesartan and captopril on left ventricular function in elderly patients with cardio-vascular disease and cardiac functional reserve

Abstract

Objective To compare effects of irbesartan and captopril on left ventricular function in elderly patients with cardiovascular disease and cardiac functional reserve .Methods 100 cases of elderly patients with car-diovascular disease were chosen ,according to a list of numbers randomly divided into the two groups ,50 cases in each group,a group with irbesartan treatment ,as the irbesartan group and the other group received captopril ,as the capto-pril group compared the two groups of patients left ventricular function and cardiac functional reserve .Results （1） Left ventricular function after the irbesartan group therapy LVDd indicators ,IVSd,LVPWd,LVEF,VE/VA,LVM was significantly better than before treatment ,the difference was statistically significant （t=31.23,18.36,28.12,46.36, 51.13,16.03,all P〈0.05）,the captopril group before and after treatment was significantly better than the treatment of various indicators,the difference was statistically significant （t=24.53,21.36,31.12,14.33,18.19,16.45,all P〈0.05）;（2） The irbesartan group of patients after treatment resting heart rate ,exercise heart rate,6min walking distance improved significantly over the treatment of former CCRI and CRI ,the difference was statistically significant （t=39.09,23.77,39.01,23.18,22.45,all P〈0.05）,after treatment with captopril treatment was significantly better than the indexes,the difference was statistically significant （t=91.21,37.16,26.74,46.33,36.74,all P〈0.05）,6min walking distance from the irbesartan group therapy ,CRI better than the captopril group ,the difference was statistically significant（t=39.02,42.14,all P〈0.05）.Conclusion Irbesartan and captopril on improving left ventricular function in elderly patients with cardiovascular disease and cardiac reserve function has a significant effect,irbesartan 6min walking distance test and cardiac reserve indices better . Key words: Cardiovascular diseases; Angiotensin Ⅱtype 1 receptor blockers; Enzyme inhibitors; Ventricular function,left; Heart function tests; Aged