Comparison of effectiveness of hyaluronic acid in combination with polylactic acid/polyglycolic acid membrane and subepithelial connective tissue graft for the treatment of multiple gingival recession defects in human: A clinical study

Abstract

Background: The patients today are increasingly conscious of personal appearance, and much attention has been focused on denuded roots that are exposed during smiling which look unesthetic. These concerns have given rise to numerous approaches for covering denuded root surfaces; however, difference of opinions is prevailing among the clinicians. Objectives: Therefore, the present study was undertaken to compare the effectiveness between hyaluronic acid (HA) in combination with polylactic acid/polyglycolic acid (PLA/PGA) membrane with that of subepithelial connective tissue graft (SCTG) for the treatment of multiple gingival recession defects. Material and Methods: Twenty-four systemically healthy patients were randomly assigned to the test guided tissue regeneration (GTR-HA) and control SCTG groups. Clinical measurements, including probing pocket depth, relative attachment level, and relative gingival margin level, were measured at baseline and at the 6-month follow-up. Result and Conclusions: After 6 months, the mean reduction in gingival recession in the test group was 2.55 ± 0.45 mm whereas in the control group, it was 2.11 ± 0.58 mm. The test group showed mean root coverage of 92.93%, and the control group showed 84% at 6 months postsurgery. When HA in combination with bioresorbable PLA/PGA membrane was compared with SCTG group; there was signifi cantly greater root coverage, clinical attachment level gain, and increased width of keratinized gingiva in the test group.