Abstract
The objective of this crossover bioavailability study on amoxicillin was to compare the bioavailability under fasting and five different diets, in twelve healthy adult male human volunteers. A single dose of amoxicillin 500 mg capsule was administered at six occasions: after overnight fasting, after two vegetarian diets (high-fat and low-fat), two non-vegetarian diets (high-fat and low-fat) and milk. Serial blood samples were collected up to 8 h after dose. Plasma concentrations were determined using a validated LC-MS/MS method. Tmax increased and AUC and Cmax values decreased in the presence of food. The non-vegetarian diets affected the rate of absorption of amoxicillin more than the vegetarian diets.
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