Abstract
PRICE et al. (1959) suggested that dietary calcium was responsible for lowering serum antibiotic levels in chickens. Increasing serum antibiotic levels by feeding compounds having a greater affinity for calcium than the antibiotic has been termed potentiation.At least four methods for increasing antibiotic levels in chickens have been published since potentiation of chlortetracycline and oxytetracycline was first reported. These methods involve the use of: (1) terephthalic acid (Price et al., 1959; Yates and Stephenson, 1959; Slinger et al., 1962; Harms et al., 1964); (2) low dietary calcium levels for a short period of time (Price et al., 1959; Patterson et al., 1960; Harms et al., 1964); (3) different calcium sources such as calcium sulfate (Donovan et al., 1962; Robblee and Clandinin, 1964); and (4) sodium sulfate (Pensack, 1963; Nelson et al., 1964; Gale and Baughn, 1965).Scott (1965) listed a number of common biological chelates for seven divalent cations… .
Published Version
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