Comparison of different propofol demands between epileptic and non-epileptic patients

Abstract

Objective To explore the different propofol demands in epileptic and non-epileptic patients through comparing the bispectral (BIS) index differences when target controlled infusion (TCI) of different concentrations of propofol is performed.Methods Forty patients,admitted to and performed general anesthesia during the surgery in our hospital from February 2009 to September 2010,were chosen and divided into epileptic group (n=20) and non-epileptic group (n=20).The patients were anesthetized with TCI of propofol; the initial target plasma concentration of propofol (Cp) was set at 1 μg/mL; when the target effect-site concentration ofpropofol (Ce) was equaled with Cp for 5 minutes,the mean BIS values in the sixth minutes were recorded.And then,the target plasma concentration was changed to 2,3,4 and 5 μg/mL,and the mean BIS values were recorded.Results when Ce is equaled with Cp at 2,3,4and 5 μg/mL for 5 minutes,the mean BIS values in the sixth minutes in non-epileptic group were slightly higher than those in epileptic group (P＞0.05).Conclusion The requirement propofol has no significant difference between epilepsy patients and non-epilepsy patients under general anesthesia with TCI of propofol. Key words: Epilepsy; Bispectral index; Propofol; Target controlled infusion