Comparison of Design Method for Making Composite of (PMMA/HA/Sericin)

Abstract

Biomaterial components (PMMA/HA/Sericin) are composite biomaterial that have complemented each other, which HA is able to improve the mechanical properties, biocompatible and osteoconductivity. PMMA has the ability biocompatible with human tissue and easy manipulated, while sericin can improve cell viability. Analysis of the composite composition is important to do more in depth, but the design method in the analysis of research also has significant impact in generating research output and prediction output. Analysis of the design method to determine the method of designing the optimal research was needed. This research used 3 factors: Poly methyl methacrylate (PMMA) powder (with concentration of 40% to 60%), Hydroxyapatite (HA) powder (with concentration of 10% to 25%) and Sericin (with concentration of 0.16% to 0.32%). This research is done to identify the effect of individual components of the composite and analyze the design method to obtain the best of diametral tensile strength (DTS) with a small error. The result of two methods was found that the 2k factorial design method give higher DTS (PHS401032 = 25.49MPa) than that of Taguchi method (PHS601532 = 24.82MPa). The error of 2k Factorial design method between validation and model prediction is 0.27%, which smaller than Taguchi method (7.45%).