Comparison of clinical efficacy of esomeprazole in treatment of gastric ulcer in young and elderly patients

Abstract

Objective To compare the clinical efficacy and safety of esomeprazole in treatment of elderly and young patients with gastric ulcer. Methods 120 cases of elderly patients with gastric ulcer and 95 cases of young and middle-aged patients with gastric ulcer were selected this study. Two groups of patients were treated with amoxicillin and clavulanate potassium dispersible tablets 0.457 g, tinidazole tablets 0.5 g and esomeprazole magnesium enteric coated tablets 20mg orally, once daily treatment 1 week for a course of treatment,1 week after continue to every morning fasting taking esomeprazole 20mg,1 times/D,treatment for 3weeks. The clinical curative effect, Hp clearance rate and incidence of adverse reactions between two groups of patients after treatment were compared. Results The total effective rate in the treatment of elderly group patients(87.50%)compared with young and middle-aged group(92.63%), there was no significant difference(χ2=1.52,P>1.52). Elderly group of patients with helicobacter pylori clearance rate(71.67%)compared with young and middle-aged group(76.84%),there was no significant difference (χ2=0.74,P>0.74). The incidence of adverse reactions(8.33%)of elderly group had obvious differences by comparing with young and middle-aged group(2.11%), and the difference was statistically significant(χ2=3.90,P<0.05). Conclusion Application of esomeprazole based triple therapy in the treatment of the elderly and young people in the gastric ulcer could heal ulcers and eradicate Hp, but young and middle-aged patients is superior to the elderly group in terms of adverse reactions. Key words: Esomeprazole; Aged; Young and middle-aged. Gastric ulcer