Abstract
IntroductionThe aim of this study is to compare performance of two biopsy approaches in patients with at least one previous negative prostate biopsy (PB): classical transrectal biopsy (ClTB) versus cognitive registration biopsy (COG-TB). Material and methodsA retrospective study of 205 patients with at least one negative PB. 144 (70.2%) patients underwent a prior mpMRI and 61 (29.8%) patients did not.Nodule classification was carried out according PI-RADS version 2. Peripheral zone (PZ) grouped pZa, pZpl and pZpm areas, transition zone (TZ) Tza, Tzp and Cz areas, and anterior zone (AZ) AS areas.COG-TB was conducted in patients with previous mpMRI (144); while in the remaining 61 (29.8%) patients a ClTB of PZ and TZ was performed.Statistical analysis was performed using Chi square and T-student tests for qualitative and quantitative variables, respectively. Multivariate analysis was carried out in order to identify predictive variables of prostate cancer. ResultsMedian patient age was 68 (IQR 62–72) years, median PSA was 8.3 (IQR 6.2–11.7) ng/ml and median previous biopsies was 1 (IQR 1–2). Digital rectal examinations (DRE) findings were normal in 169 (82.4%) patients and suspicious in 36 (17.6%) patients (cT2a-b in 34 patients and cT2c in 2). Median prostate volume was 48 (IQR 38–65) cc. Statistically significant differences in PSAD between both groups were found (p=0.03).Transrectal ultrasound (TRUS) showed hypoechoic nodules in 8 (13.1%) ClTB patients and in 62 (43.1%) COG-TB patients (p=0.0001).The median number of biopsy cylinders per set of prostate biopsies was 10 (IQR 10–10) in ClTB group and 11 (IQR 9–13) in COG-TB group (p=0.75).Cancer was diagnosed in 74 (36.1%) patients: of them, 10 (16.4%) were ClTB patients and 64 (44.4%) COG-TB (p=0.0001).Tumors classification was as follow: ISUP-1: 34 (45.9%), ISUP-2: 21 (28.4%), ISUP-3: 9 (12.2%), ISUP-4: 7 (9.5%) and ISUP-5: 3 (4.1%). No significant statistical differences were found (p=0.89). The median number of biopsy cylinders impaired per set of prostate biopsies was 1 (IQR 1–5) in ClTB group and 2 (IQR 1–4) in COG-TB group (p=0.93).Regarding independent predictive variables for prostate cancer the results were: age (OR=12.05; p=0.049), suspicious DRE (OR=2.64; p=0.04), hypoechoic nodule (OR=2.20; p=0.03) and mpMRI +COG-TB sequence (OR=3.49; p=0.003). ConclusionsIn patients with at least one negative PB, mpMRI+COG-TB sequence improves 3.5 (OR=3.49) times the diagnosis prostate vs. ClTB.
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