Abstract
Objective: To determine the mean endothelial cell change in patients undergoing vitrectomy with silicon oil replacement and to compare the corneal endothelial cell loss frequency of phakic, pseudophakic, and aphakic Vitrectomized Silicone Oil-filled eyes.
 Study Design: Cross-sectional Study.
 Place and Duration of Study: Retina Department, Al-Shifa Trust Eye Hospital, Rawalpindi Pakistan, from Aug 2020 to Jan 2021.
 Methodology: A total of one hundred patients of either gender, aged 50-80 years, who underwent vitrectomy with silicon oil replacement were enrolled in the study. Patients were assigned to one of the three groups based on their lens status, phakic,pseudophakic and aphakic. Mean endothelial count density before and three months after vitrectomy was estimated in all the patients.
 Results: Cell loss was higher in the pseudophakic and aphakic groups than in the phakic groups. More than 5% cell loss at three months was observed in 11.8%, 21.2% and 33.3% in the phakic, pseudophakic, and aphakic groups, respectively (p-value 0.102).
 Conclusions: Mean endothelial cell loss was higher in the pseudophakic and aphakic groups than in the phakic groups.
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