Abstract
Methods 22 patients with known or suspected CAD underwent both N-Ammonia PET and CMR adenosine stress and rest perfusion imaging prior to diagnostic coronary Xray angiography (CXA). CMR perfusion imaging was performed at 1.5T with a kt-accelerated steady-state free-precession sequence. Data analysis was blind. A significant coronary artery stenosis was defined as at least 70% diameter reduction or a fractional flow reserve <0.8. Sensitivity and specificity for PET and CMR versus invasive angiography were calculated. Localization of ischaemia was assessed in patients with CAD by classifying territories that were ischaemic on imaging as either supplied by, or as remote from, a stenotic artery.
Highlights
Positron Emission Tomography (PET) is regarded as the non-invasive reference-standard for assessment of myocardial perfusion
In the 18 patients with coronary artery disease (CAD) there was detectable ischaemia in 79% of the coronary artery territories supplied by significantly stenotic arteries with both PET and Cardiac Magnetic Resonance (CMR)
Ischaemia was detected in 20% of remote territories with PET and 17% with CMR. 50% (n=3) of the territories with remote ischaemia on PET imaging had remote ischaemia on CMR imaging
Summary
PET is regarded as the non-invasive reference-standard for assessment of myocardial perfusion. There are few data comparing the performance of CMR against PET perfusion imaging, in patients with a high prevalence of CAD. Novel MR techniques, e.g. based on kt acceleration techniques, allow perfusion imaging with improved spatial resolution
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