Abstract
Background Myocardial extracellular volume (ECV) fraction [1], derived from pre- and post-contrast cardiac T1 measurements, is an emerging biomarker of diffuse cardiac fibrosis. The major benefits of ECV over post-contrast cardiac T1 is that the former is less sensitive to confounders such as contrast agent type and dosage, specific delayed imaging time, renal function, and magnetic field strength. Recent studies using inversion-recovery (IR) based T1 mapping in control human subjects[2] and patients[3] reported that ECV measured with a bolus injection of contrast agent agrees well with ECV measured with a slow infusion of contrast agent. It is unknown if this approximation holds in canines which are frequently used in preclinical research. We sought to compare canine ECV measurements derived from bolus and slow infusion protocols. Methods
Highlights
Myocardial extracellular volume (ECV) fraction [1], derived from pre- and post-contrast cardiac T1 measurements, is an emerging biomarker of diffuse cardiac fibrosis
Eighteen mongrel dogs with normal myocardium were imaged at 3T (Verio, Siemens)
Cardiac T1 maps were acquired in 3 short-axis planes using the arrhythmia-insensitive-rapid (AIR) cardiac T1 mapping pulse sequence based on B1-insensitive saturation-recovery of magnetization preparation [4], with the following imaging parameters: spatial resolution = 1.4 × 1.4 × 7.0 mm, temporal resolution = 217 ms, saturationrecovery time = 600 ms
Summary
Comparison of canine ECV measurements derived from CMR: bolus injection vs. slow infusion of Gd-BOPTA. Kyungpyo Hong1*, Eugene G Kholmovski, Christopher J McGann, Ravi Ranjan, Daniel Kim. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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