Abstract
ObjectiveTo determine agreement in oxygen consumption (V˙O2) values calculated using Sykes’ formula V˙O2 = (FiO2 – Fe′O2) * V˙E (where Fi and Fe are the inspired and end-tidal fractional concentrations of O2, respectively, and V˙E is minute volume) with values derived using Brody’s formula (V˙O2 = 10 kg3/4). It was hypothesized that the two methods would not yield statistically significant differences in calculated values. Study designProspective, clinical, pilot study. AnimalsA total of 22 client-owned dogs. MethodsDogs undergoing surgery were anaesthetized with either isoflurane or sevoflurane. The V˙E, FiO2 and Fe′O2 were measured during mechanical ventilation of the lungs (tidal volume 10 mL kg–1; respiratory rate: 8–12 breaths minute–1). Oesophageal temperature was maintained between 37.0 °C and 38.5 °C. Values for V˙O2 derived by Sykes’ and Brody’s methods were compared and agreement was determined using Bland–Altman analysis. ResultsMean V˙O2 values were 4.67 ± 0.51 mL kg–1 minute–1 and 5.32 ± 1.69 mL kg–1 minute–1 calculated using Brody’s formula and Sykes’ equation, respectively. There was greater variability in the values obtained from Sykes’ equation. The Bland–Altman plot revealed a proportional error with correlation but poor agreement between values. Conclusions and clinical relevanceBoth methods yielded V˙O2 values of approximately 5 mL kg–1minute–1 with no statistically significant differences between the two methods.
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