Abstract
To compare tibial bone texture between Kashin-Beck disease (KBD) patients and normal individuals from plain radiographs using an advanced image analysis. Plain knee radiographs were obtained from KBD patients (n = 49) and age-matched healthy controls (n = 98). KBD were graded with diagnostic criteria WS/T 207-2010. The textural values related to bone structure from medial and lateral tibial subchondral and trabecular bones were evaluated using entropy of Laplacian-based image (ELap), entropy of local binary patterns (ELBP), homogeneity indices (HI) of local angles (HIMean, HIPerp and HIParal), and fractal dimensions from horizontal (FDHor) and vertical (FDVer) structures. KBD patients were shorter in height and lighter in weight, and their tibial width was wider than controls. Anatomical angle of KBD patients showed more genu valgus. Total KBD patients and subgroups had higher ELap, HIMean, HIPerp and HIParal in detected tibial subchondral and trabecular bones than controls, except ELap in lateral subchondral bone. ELBP, FDHor and FDVer from the detected tibial bone in KBD patients and subgroups were lower than controls, except FDVer in lateral trabecular bone. Our results indicate that micro-scale in bone texture in KBD-affected knees can be quantitatively examined from plain radiographs using an advanced image analysis.
Highlights
Kashin-Beck disease (KBD) is a chronic endemic and degenerative form of osteoarthritis (OA), which is distributed primarily in agricultural regions of southeastern Siberia, northern Korea, and China[1,2,3]
entropy of Laplacian-based image (ELap) in total KBD patients and all KBD subgroups was higher than the controls, as well as it was lower in KBD grades 2 and 3 compared to grade 1 (Fig. 2a, Table 3)
entropy of local binary patterns (ELBP), FD of horizontal structures (FDHor) and FD of vertical structure (FDVer) were lower in total KBD patients and various KBD subgroups than the controls (Figs 2c, and 4a,c, Table 3)
Summary
Kashin-Beck disease (KBD) is a chronic endemic and degenerative form of osteoarthritis (OA), which is distributed primarily in agricultural regions of southeastern Siberia, northern Korea, and China[1,2,3]. It causes pain, discomfort and disability to work already at young age. Macro-scale changes of bone tissues can be observed from plain radiographs which provide very useful morphological information of the disease-affected bone density and structure. We hypothesized that bone structure-related texture parameters measured with Laplacian-based, LBP-based and FSA-based methods are different between healthy individuals and KBD patients or their subgroups
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