Abstract
Assay methods for varicella-zoster virus (VZV) susceptibility to acyclovir (ACV) of VZV were compared by using cell-free (CF) and cell-associated (CA) virus of 6 × plaque-purified VZV. The 50% effective doses (ED 50) of ACV, as required to reduce virus plaque formation by 50%, were about 8 times higher for CA virus than for CF virus. Also, the ED 50 of 1-β- d- arabinofuranosyl-(E)-5-(2- bromovinyl)uracil (BVaraU) for CA-VZV was higher than for CF-VZV, and fresh clinical isolates of VZV gave higher ACV ED 50 values than CF virus. CA virus prepared at various times after CF virus infection showed a gradual increase of the ACV ED 50 with time, ranging from the ED 50 for CF virus to that for CA virus.
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