Abstract
To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6h of administration. Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6h after administration of 50µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval. 102 patients were studied, 51 received sublingual misoprostol, and 51 received vaginal misoprostol. There was a statistically significant difference in cervical modifications in global terms regardless of the administration route at 6h (P < 0.05). When analyzing each group, there was no significant difference for the mean and standard deviation for Bishop score for sublingual and vaginal route (P = 0.761). There was no significant difference in terms of mode of delivery, Apgar score, cord pH, nor in the presence of complications. There is no statistically significant difference in terms of administration route for cervical ripening using misoprostol 50µg, whether it was sublingual or vaginal. NCT02732522. Registry website: https://clinicaltrials.gov/ .
Published Version
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