Comparison between the effect of different medical drugs used to improve endometrial receptivity in patients with thin poorly vascularized endometrium

Abstract

Background: Pregnancy has been one of life’s great mysteries. The endometrium is where life begins, and a receptive endometrium lies at the crossroads of menstruation and pregnancy. Aim of the study: To evaluate the effects of different medical drugs used routinely to improve endometrial thickness, vascularity, and pregnancy rates and to find out the best medical protocol could be used to improve endometrial thickness, vasculature, and pregnancy rate for patient with thin and poorly vascularized endometrium regardless the cause. Materials and methods: The study was carried out on 200 infertile women who have thin , poorly vascularized endometrium, after they matched the inclusion and exclusion criteria , those patients were divided randomly into five groups ; 40 patient in each group, group A received esterofem oral 2mg tablet every 12 hours from day 2 of menstrual cycle till the day of ovulation trigger , group B received vagifem vaginal tablets 25 microgram from the fourth day of menstrual cycle for 15 days or till the day of ovulation trigger, group C received sildenafil citrate gel 3 gm which containing 37.5 mg sildenafil every 12 hours from the 2nd day of menstruation till the day of ovulation trigger.