Abstract
Objective:This study was aimed to compare and analyze the effects and safety of minimally invasive and craniotomy in the treatment of hypertensive intracerebral hemorrhage.Methods:A total of 130 patients with hypertensive intracerebral hemorrhage were recruited. The patients were randomly divided into two groups (research and control group). Research group was treated with endoscopic minimally invasive surgery, while control group was treated with craniotomy and hematoma clearance. The basic situation, clinical effects, prognosis, nerve function and inflammatory factors of the two groups were compared while the condition of postoperative complications was also observed.Results:The operative time of patients in research group showed statistically significant (P<0.05) difference when compared with control group. Hematoma clearance rate and intraoperative blood loss of research group was significantly better than control group. There was no significant difference (P>0.05) between the two groups in preoperative hemorrhage and edema around the hematoma, however hemorrhage and edema around the hematoma after four weeks of surgery in the research group was significantly (P<0.05) lower than control group. After four weeks of treatment, the BI and SSS score, SP and IL-2 level of the research group were significantly higher than control group (P<0.05), while MRS score, IL-6, hs-CRP, TNF-α and SF was significantly lower than control group (P<0.05).Conclusion:Compared with craniotomy, minimally invasive surgery is more effective in the treatment of hypertensive intracerebral hemorrhage, as well as it is more conducive to restore neurological function, improve prognosis and reduce serum inflammatory factor levels.
Highlights
Hypertensive cerebral hemorrhage is a spontaneous intracerebral hemorrhage, which is caused by hypertension and the main pathological basis is hypertension and arteriosclerosis.[1]Arteriosclerosis results in thickening of artery intima and atheromatous plaque, which makes the lumen relatively narrow
Comparison of the basic and clinical effects: The operative time of patients in research group showed statistically significant difference when compared with control group (P
There was no significant difference between the two groups in preoperative hemorrhage and edema around the hematoma, but the situation of hemorrhage and edema around the hematoma within four weeks after surgery in the research group was significantly lower than control group (P
Summary
Hypertensive cerebral hemorrhage is a spontaneous intracerebral hemorrhage, which is caused by hypertension and the main pathological basis is hypertension and arteriosclerosis.[1]Arteriosclerosis results in thickening of artery intima and atheromatous plaque, which makes the lumen relatively narrow. Hypertensive cerebral hemorrhage is a spontaneous intracerebral hemorrhage, which is caused by hypertension and the main pathological basis is hypertension and arteriosclerosis.[1]. There are a variety of surgical procedures, and the prognosis is not the same.[4,5] The traditional surgical treatment of hypertensive cerebral hemorrhage is craniotomy which has good effect on removing hematoma and hemostasis. Craniotomy often damages the surgical approach and the surrounding normal brain tissues, subsequently reduce the efficacy of prognosis of the patients.[6] With the advancement of minimally invasive endoscopic technique, endoscopic surgery has good application prospectives.[7] Our objective was to compare and analyze the effects and safety of minimally invasive and craniotomy in the treatment of hypertensive intracerebral hemorrhage
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