Effects of early minimally invasive intracranial hematoma removal on hypertensive intracerebral hemorrhage and CRP, IL-4 and IL-10 levels

Abstract

Objective To investigate the effects of early minimally invasive intracranial hematoma removal on hypertensive intracerebral hemorrhage and the levels of C-reactive protein (CRP), interleukin-4 (IL-4) and interleukin-10 (IL-10). Methods Eighty-four patients with hypertensive cerebral hemorrhage were analyzed retrospectively. Patients were randomly divided into control group and study group according to treatment methods, with 42 cases in each group. The control group was treated with scavenging of bone window hematoma, and the study group was treated with early minimally invasive intracranial hematoma removal, all patients were followed up for two weeks. The clinical effects of two groups were compared, the levels of serum CRP, IL-4, IL-10 before and after treatment, the condition of nerve function defect and the incidence of complications before and after treatment were compared between the two groups. Results The total effective rate of treatment in study group was 95.24% (40/42), which was significantly higher than that of control group [(78.57% (33/42)], and the difference was statistically significant (P<0.05). After treatment, serum CRP, IL-4, IL-10 levels in study group were (13.7±3.5) mg/L, (15.4±3.6)ng/L, (10.1±2.2)ng/L, which were significantly lower than those in control group (16.8±4.1)mg/L, (18.2±4.0)ng/L, (14.3±2.6)ng/L, there was a statistically significant difference (P<0.05). At 1 and 2 weeks after treatment, the NIHSS scores in study group were (24.4±3.4) and (9.4±2.2) respectively, which were significantly lower than those in control group (33.2±4.1, 14.5±3.1), the difference was statistically significant (P<0.05). The incidence of complications in study group (4.76%) was significantly lower than that of control group (21.43%), the difference was statistically significant (P<0.05). Conclusions Early minimally invasive intracranial hematoma is effective in the treatment of hypertensive intracerebral hemorrhage, and it can effectively control the levels of CRP, IL-4 and IL-10, promote the recovery of neurological function, and reduce the incidence of complications. It is worth popularizing in clinical application. Key words: Hypertensive intracerebral hemorrhage; Early minimally invasive intracranial hematoma removal; Efficacy; Inflammatory factors; Nerve function