Comparison among different dosages of dexmedetomidine combined with sufentanil for tracheal intubation in awake patients

Abstract

Objeetive to compare the effect of different dosages of dexmedetomidine (DEX) combined with sufentanil for tracheal intubation in awake patients. Methods Ninety patients with Mallampati test Ⅲ-Ⅳ were randomly assigned into three groups (n=30).Group Ⅰ received intravenously pumping DEX 0.8 μg/kg plus sufentanil 0.1 μg/kg,group Ⅱ with DEX 1.0 μg/kg plus sufentanil 0.1 μg/kg,group Ⅲwith DEX 1.2 μg/kg plus sufentanil 0.1 μg/kg.mean arterial pressure (MAP),heart rate(HR),oxygen saturation (SpO2) of patients were recorded at the time points of entering the operationroom (T0),before intubation (T1) and intubation (T2),respectively.Serial blood samples were obtained for analysis of plasma cortisol concentrations at each time points.The responses at the intubation,and Ramsay scores before intubation were recored.Memory of intubation was inquired after operation. Results HR in patients of group Ⅱ at T1(68±9) beats/min were significantly decreased compared with that at T0(78±10)beats/min (P＜0.05),HR inpatients of group Ⅲ at T1 (68±17) beats/min and T2 (64±6) beats/min are significantly decreased compared with that at T0(81±12) beats/min(P＜0.05).HR in patients of group Ⅱ (68±9) beats/min and Ⅲ (68±17) beats/min at T1 are significantly decreased compared with that of group Ⅰ (81±12) beats/nin(P~05) and HR in patients of group Ⅲ at T2(64±6) beats/min are significantly decreased compared with that of group Ⅰ (85±15) beats/min(P＜0.01).MAP in patients of group Ⅲ at T2(111±-9) mm Hg (1 mm Hg=0.133 kPa) are significantly increased compared with that at T0(98±10) mm Hg(P＜0.05 ).MAP in patients of group Ⅱ and Ⅲ at T1 and T2 are significantly increased compared with that of group Ⅰ (P＜0.05).Ramsay score in patients of group Ⅱ and Ⅱ at the moment of intubation are significantly higher than that in patients of group Ⅰ (P＜0.05). Conclusions These results show that it is optimal for 1.0 μg/kg DEX combined 0.1 μg/kg sufentanil used for awake intubation. Key words: Dexmedetomidine; Sufentanil; Intubation,intratracheal