Abstract
Objective : To compare the local anaesthetic action of central neuron sodium channel blockers Phenytoin Sodium, Sodium Valproate and Carbamazepine with peripheral neuron sodium channel blockers Lignocaine using Infiltration anaesthesia in guinea pigs Material and Methods: In the present study,the local anaesthetic effect of Lignocaine with concentration of 0.2%, 0.1% ,0.05% was compared with Phenytoin Sodium, Sodium Valproate and Carbamazepine in concentrations of 0.2%, 0.1% ,0.05% using different dilutions of 0.05N,0.1N,0.2N HCL in guinea pig by pricking on the skin produces a squeak or movement indicating pain is produced. Results : The results of our present study suggest onset of local anaesthesia with lignocaine 0.2% is significantly fast when compared with concentration of 0.1%, and 0.05% indicating it has better efficacy when using for various  local anaesthetic procedures. In addition onset of local anaesthesia with Phenytoin sodium concentrations of 0.2%, 0.1% ,0.05%  is fast  when compared with Sodium valproate concentrations of 0.2%, 0.1% ,0.05%  and Carbamazepine concentrations 0.2%, 0.1% ,0.05%. Conclusion: Among antiepileptic drugs with local anaesthesia and  membrane stabilizing activity Phenytoin sodium showed fast on set of action when compared with sodium valproate and Carbamazepine indicating it has better efficacy. Keywords : Local Anaesthetics, Membrane Stabilizing, Infiltration anaesthesia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
