Abstract
To design efficient nanoparticles for bioimaging, it is necessary to obtain nanoparticles with desired cellular uptake and biofunction. There are many studies have shown that cellular uptake largely depends on the geometric properties of nanoparticles. In this work, the organic nanoparticles with rod-like and spherical shapes were fabricated, and their cellular behaviors were studied and compared in detail via cellular uptake and bioimaging effect. The nanoparticles with spherical and rod-like morphology both can be internalized by HeLa and HepG2 cells, but the rod-like nanoparticles showed better imaging performance than their spherical counterpart. Above results presented that the rod-like nanoparticles possess great potential for bioimaging in efficient delivery and ideal imaging efficacy. Our studies may provide useful and fundamental information for designing efficient bioimaging systems.
Highlights
Nanomedicines are very important for various biomedical applications because if the prolong circulation times, overcome biological barriers, and reduce system side effects (Lee et al, 2012; Kunjachan et al, 2015)
According to our previous work, BDP could self-assemble into rod-like nanoparticles (BDP self-assembly, BSA NRs)
The size distribution and morphology of BSA NRs/BPF NPs were wellcharacterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), and confocal fluorescence microscopy (CLSM)
Summary
Nanomedicines are very important for various biomedical applications because if the prolong circulation times, overcome biological barriers, and reduce system side effects (Lee et al, 2012; Kunjachan et al, 2015). Particles with diameter in 50–100 nm show a suitable size range for maximizing tumor accumulation and minimizing the ensuing clearance (Black et al, 2014). Besides the size, another important parameter is the morphology of nanomedicines (Herd et al, 2013; Blanco et al, 2015). Researchers have systematically studied the different of nanomedicines with various shapes on cellular internalization (Alemdaroglu et al, 2008; Chauhan et al, 2011) Compared to their spherical counter parts, the rod-like nanoparticles have more advantages in their cellular behaviors.
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