Abstract
BackgroundRecently alternative therapies such as the use of diode laser therapy have been introduced for recurrent herpes labial infection. The aim of this study was to evaluate the effectiveness of diode laser for treatment of recurrent herpes labialis.Material and MethodsThis was single-blind randomized clinical trial to evaluate the efficacy of diode laser for the treatment of recurrent herpes labial. In total, 60 patients whit recurrent herpes simplex labialis were selected and randomly divided in to three groups. 20 patients received treatment whit diode laser (at a wavelength of 870 nm, energy density 4.5 j/cm2), 20 patients were treated with acyclovir cream 5%, 20 patients received treatment with laser-off (placebo). The end point was lesions crusting. Data analyzed by Tukey HSD Test and One-way ANOVA (at a significance level of 0.05) in SPSS-20 software.ResultsThe mean length of recovery time (day) in the laser, off laser, and acyclovir groups was 2.20±0.41, 4.30±1.03, and 3.4±1.142, respectively. There is a significant difference between three groups in this regard (P<0.0001). The mean duration of pain (day) was 1.35±0.74, 2.65±1.27, and 2.30±0.92 for laser, off laser, and acyclovir groups, respectively (P<0.0001).ConclusionsTreatment with diode laser reduced the length of recovery time and pain severity faster than treatment with acyclovir cream. Key words:Recurrent herpes labial, Acyclovir, Low level laser therapy.
Highlights
Recurrent herpes labialis (RHL) occurs in 20% to 40% of young adult population
Muñoz Sanchez et al [7] conducted a study in 2012 in which they compared the effect of level laser therapy (LLLT), 670 nm, on herpes labialis with acyclovir
This study aimed to evaluate the effect of Low level laser therapy on the treatment of patients with herpes labialis compared to acyclovir cream
Summary
Recurrent herpes labialis (RHL) occurs in 20% to 40% of young adult population. The lesions have prodromal symptoms, including itching, tingling or burning in 50% of cases and eventually develop papules, vesicles, ulcers, and crust. RHL is a self-limiting condition, the use of topical antiviral medications reduces viral shedding and infectivity These agents decrease pain level, lesion size and duration of symptoms [1]. Low level laser therapy (LLLT) has been considered as a possible treatment for herpes labialis in recent years. This study aimed to evaluate the effect of Low level laser therapy on the treatment of patients with herpes labialis compared to acyclovir cream. Alternative therapies such as the use of diode laser therapy have been introduced for recurrent herpes labial infection. The aim of this study was to evaluate the effectiveness of diode laser for treatment of recurrent herpes labialis. Conclusions: Treatment with diode laser reduced the length of recovery time and pain severity faster than treatment with acyclovir cream
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