Abstract
DNA condensation is of great interest due to its fundamental biological importance. With the discovery of the important roles of RNAi, recent attention has been focused on efficient packaging of dsRNA for therapeutics. In this study, we applied UV spectroscopic and small angle x-ray scattering to investigate the mechanism of RNA condensation. Our results show that double-strand DNA and RNA behave very differently under certain ionic conditions. The forces that lead to side-by-side attraction and subsequent condensation of DNA molecules may be highly correlated with the differing geometric property of RNA and DNA.
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