Abstract
Male Wistar (rattus norvegicus) and desert rats (meriones crassus) were given a single dose of 200 mg/kg of clofibrate (CPIB) p.o. and liver tissue was analysed by ultrastructural morphometry. CPIB induced a biphasic reaction pattern of hepatocellular organelles both in Wistar and desert rats. In the initial phase (2–5 h) the volume share of mitochondria per hepatocyte increased in both strains. In the hepatocytes of desert rats the total number of mitochondria increased whereas the volume of the single mitochondrium remained constant. In contrast, in Wistar rats the volume of the single mitochondrium showed a threefold increase. In the initial phase the number of microbodies both in Wistar and desert rats decreased, but the single volume doubled.
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