Abstract
Comparison of the transcriptomes of pluripotent embryonic stem cells, multipotent adult progenitor cells and lineage restricted mesenchymal stem cells identified a unique gene expression profile of multipotent adult progenitor cells.
Highlights
Several populations of postnatal stem cells, such as multipotent adult progenitor cells (MAPCs), have been described that have broader differentiation ability than classical adult stem cells
Two independently and clonally isolated mMAPC populations - mMAPC-1 and mMAPC-2 - expressed the mRNA for the transcription factor
We have recently found that both mouse and rat MAPCs express Oct4 protein, which is localized in the nucleus [14]
Summary
Several populations of postnatal stem cells, such as multipotent adult progenitor cells (MAPCs), have been described that have broader differentiation ability than classical adult stem cells. We compare the transcriptome of pluripotent embryonic stem cells (ESCs), MAPCs, and lineage-restricted mesenchymal stem cells (MSCs) to determine their relationship. In contrast to embryonic stem cells (ESCs), which can give rise to all cell types in an adult organism and are called pluripotent [5], HSCs, MSCs, and NSCs are termed multipotent. Described a population of cells termed multipotent adult progenitor cells (MAPCs), which expand in vitro without obvious senescence, and can, at the clonal level, generate mesenchymal-lineage cells and endothelium, hematopoietic cells, hepatocyte-like, and neuroectoderm-like cells in vivo and/or in vitro. Since the characterization of MAPCs, several other groups have described cells with similar abilities that can be isolated from bone marrow (human bone marrow stem cells (hBMSC), marrow-isolated adult multilineage inducible (MIAMI) cells, and pre-MSCs), umbilical cord blood (unrestricted somatic stem cells (USSCs)), placenta, muscle, and other tissues [8,9,10,11,12,13]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call