Comparative study to evaluate the role of Letrozole and low dose human menopausal gonadotrophin on ovulation induction in polycystic ovarian syndrome patients

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a multifaceted syndrome that affects multipleorgan systems with significant metabolic and reproductive manifestations. Treatment must be individualized on the basis of patient’s presentation, and desire for the pregnancy. Objective: To study the role of letrozole (LE) and low dose human menopausal gonadotrophen (HMG) on ovulation induction in the polycystic ovarian syndrome patients. Material & Methods: The present hospital based double blind clinical trial, recruited total 105 patients’ of age 21 to 35 years women with PCOS among those attending the gynecology outpatient’s clinic in Hind Institute of Medical Sciences Safedabad Barabanki in the period from Sept 2018 to Sept 2021 were enrolled. Observation: Endometrial thickness, and number of the mature follicles of the LE+HMG group were higher significantly than other two groups (P<0.001). Effects of different regimens on pregnancy. Pregnancy rate of LE+HMG group was 54.3%, which was insignificantly higher than LE group (31.4%) and HMG group (34.3%) (P>0.05). There were also no statistically significant differences in rate of abortion, and rates of multiple pregnancy among the three groups. All the three groups suffered from OHSS, but the incidences rates were comparable.