Therapeutic Efficacy of Promoting Ovulation Combining Intrauterine Insemination on Infertility

Abstract

Objective To discuss the clinical pregnancy outcomes of three methods [Clomiphene (CC), Letrozole (LE) and human menopausal gonadotropin (HMG)] of promoting ovulation combining intrauterine insemination (IUI) on infertility. Methods From October 2011 to September 2012,a total of 98 cases with 157 treatment cycles, due to ovulation disorders, polycystic ovary syndrome, follicular dysplasia and other reasons, who were received IUI treatment in Taizhou People' s Hospital were retrospectively analyzed. According to different ovarian simulation potocols, they were incorporated into three groups: CC group (n=36,60 treatment cycles), LE group (n=34, 55 treatment cycles) and HMG group (n= 28, 42 treatment cycles). There were no significant differences on age and duration of infertility among three groups (P > 0.05). The follicle number, size and endometrial thickness on the day of intramuscular injection of human chorionic gonadotropin (hCG), and clinical pregnancy rates, multiple pregnancy rates and abortion rates among three groups were compared. In this study, the procedure followed in line with Taizhou People's Hospital Ethics Committee to develop a standard human trials to obtain approval of the committee, grouping the consent of the subject's consent and with the signing of informed consent in clinical research. Results The endometrial thickness on the day of intramuscular injection of hCG of LE group was higher than that of CC group and HMG groups (t= - 9.329, P 0.05). The follicle number of HMG group on the day of intramuscular injection of hCG was much more than that of CC group and LE group (t= –1.137, P 0.05). Conclusions LE was superior to CC and HMG in the aspect of improving endometrial thickness, while HMG was superior to CC and LE in promoting follicle development. Key words: [Key words】Ovulation induction; Insemination,artificial; Pregnancy outcome