Abstract
Comparison between the efficacy of ceftriaxone and monocytes on improvement of neuron protection and functional recovery after spinal cord injury (SCI) in rat. Rats were randomly divided into three groups of ten. Spinal cord injury was performed on rats under general anesthesia using the weight dropping method. Ceftriaxone was injected intraperitoneally 200 mg/kg/day for seven days after SCI. Monocytes were injected 2 × 105 cells 4 days after SCI. Hind limb motor function was assessed using the Basso, Beattie and Bresnahan (BBB) scale. Corticospinal tract (CST) axons were traced by injection of biotin dextran amine (BDA) into the sensorimotor cortex. There were statistically significant differences in BBB scores in ceftriaxone in comparison to both monocytes receiving and control groups. On the other hand there were statistically significant differences in axon counting in both ceftriaxone and monocytes receiving groups in comparison to control group. Our findings suggest that ceftriaxone improves functional recovery more effective than monocytes in rats after SCI. These results are from an experimental model and validation is required for further investigation.
Highlights
As many as 500,000 people suffer a spinal cord injury (SCI) each year
Our findings suggest that ceftriaxone improves functional recovery more effective than monocytes in rats after SCI
Following SCI and administration of monocytes, there was no correlation with the control group but in contrast to the above finding, there was a correlation with the first group (Figure 1)
Summary
As many as 500,000 people suffer a spinal cord injury (SCI) each year. Up to 90% of SCI cases are due to traumatic causes such as road traffic crashes, falls and violence.[1,2] early interventions can likely spare most tissues and cells, producing a minimum degree of deficit and lead to maximum functional recovery. Extensive use of antiinflammatory agents such as methylprednisolone has been implicated in SCI.[3,4] despite the initial hopefulness, methylprednisolone has not demonstrated a significant clinical efficacy.[5,6,7] secondary injury after SCI can make post-traumatic inflammatory reactions. Ceftriaxone has recently been discovered to up-regulate GLT-1 expression in the CNS through increasing GLT-1 transcription.[12,13] ceftriaxone improves neuron protection and functional recovery in rat spinal cord injury models[14] and recent studies have extensively focused on molecular and cellular therapeutic interventions. The present study has designed to compare the effects of monocytes and ceftriaxone on spinal cord injury in the rats
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