Abstract

Comparative study on Insulin-Like Growth Factor I (IGF-I) plasma concentrations in new-born horse foals, donkey foals and calves

Highlights

  • Starting from the last stage of pregnancy and especially during the early neonatal phase, the new born should provide multiple adjust­ ments to adapt to the extra uterine life

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  • Fetal growth is strictly related to the delivery of nutrients through the placenta, which regulates IGF-I fetal concentrations; with the disruption of the feto-maternal placental interface at birth, in human babies a decrease of postnatal IGF-I plasma levels can be observed, probably due to a low endogenous production

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Summary

Introduction

Starting from the last stage of pregnancy and especially during the early neonatal phase, the new born should provide multiple adjust­ ments to adapt to the extra uterine life. The endocrine system, considered functional already at birth, should continue its maturation during the early neonatal life [1,2,3,4]. Several hormones and growth factors interact and work synergically to allow a correct somatic growth and development, under the regulation of the hypothalamic-pituitary axis [2,5,6]. Before birth, fetal growth and development are mainly regulated by IGF-II [12], during the postnatal period the most important growth regulator is represented by the IGF-I [13]. The somatotropic axis and IGFs are involved in the GastroIntestinal Tract (GIT) development, and especially in the proliferation and maturation ofenterocytes as demonstrated in newborn calves [16,17,18]

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