Abstract
Comparative study on Insulin-Like Growth Factor I (IGF-I) plasma concentrations in new-born horse foals, donkey foals and calves
Highlights
Starting from the last stage of pregnancy and especially during the early neonatal phase, the new born should provide multiple adjust ments to adapt to the extra uterine life
(p
Fetal growth is strictly related to the delivery of nutrients through the placenta, which regulates IGF-I fetal concentrations; with the disruption of the feto-maternal placental interface at birth, in human babies a decrease of postnatal IGF-I plasma levels can be observed, probably due to a low endogenous production
Summary
Starting from the last stage of pregnancy and especially during the early neonatal phase, the new born should provide multiple adjust ments to adapt to the extra uterine life. The endocrine system, considered functional already at birth, should continue its maturation during the early neonatal life [1,2,3,4]. Several hormones and growth factors interact and work synergically to allow a correct somatic growth and development, under the regulation of the hypothalamic-pituitary axis [2,5,6]. Before birth, fetal growth and development are mainly regulated by IGF-II [12], during the postnatal period the most important growth regulator is represented by the IGF-I [13]. The somatotropic axis and IGFs are involved in the GastroIntestinal Tract (GIT) development, and especially in the proliferation and maturation ofenterocytes as demonstrated in newborn calves [16,17,18]
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