Comparative Study On Haemodynamic Responses During Intubation Using Etomidate Propofol And Thiopentone In Laparoscopic Cholecystectomy Surgeries

Abstract

DOI:http://dx.doi.org/10.15520/ij mhs.2015.vol5.iss4.80.150-158 Tracheal intubation provides a patent airway. Direct laryngoscopy and intubation are noxious stimuli. Significant hypertension and tachycardia are associated with tracheal intubation under light anaesthesia. Nowdays, prevention of hemodynamic response by use of premedications & induction agents, thereby increasing the depth of anaethesia. During laparoscopic cholecystectomy, haemodynamic changes occur to a greater extent than other non laproscopic surgeries. In my study Ninety (90) patients of ASA I & II physical status of either sex schedule for elective laparoscopic cholecystectomy surgeries. All the patients were preoxygenated with O2 followed by Inj. Nalbuphine 0.1 mg / Kg & midazolam 0.05mg / Kg i.v. followed by induction agent either thiopentone, propofol or etomidate doses of 5mg/kg,2mg/kg,0.3mg/kg respectively & muscle relaxant rocuronium 1mg/kg was given. Laryngoscopy and intubation were done after complete jaw relaxation. Injection glycopyrolat 4 mg/ Kg IM, injection ranitidine 50mg and injection metoclopamide 10mg were given IV to the patients 45 minute before surgery. Haemodynamic parameters at pre induction, post induction and after intubation at 0min,1min,3min,5min & 10min were taken into account for evaluation obtained from each group were analyzed statistically and compared by Average Standard Deviation and t test . p value less than 0.05 was considered significant and more than 0.0.5 was considered not significant. The finding of study, no significant change in HR,SBP,DBP,MAP in post induction and after intubation in etomidate group.