Abstract
Aims: Presently Propofol and Etomidate are popular as rapid acting inducing agents. Due to reflex sympathetic stimulation, direct laryngoscopy and endotracheal intubation typically cause a cardiovascular stress response characterized by hypertension and tachycardia. This study is conducted to compare the effects of these two drugs on hemodynamic responses during induction and endotracheal intubation, to compare time of induction to choose the better induction agent and to study adverse effects of the two drugs, if any.
 Study Design: Prospective double blind study
 Place and Duration of Study: Department of anaesthesiology Dr D.Y Patil medical college hospital and research centre Pimpri Pune Duration -Sept.2018 -sept 2021.
 Methodology: This is prospective randomized double-blind study. 60 ASA I and II patients randomly divided into two groups group P and group E of 30 each of either sex in age group of 18-65 years posted for elective surgery under general anesthesia. Group P: (n-30) received 2.5mg/kg Propofol and Group E:(n-30) received 0.3mg/kg Etomidate for induction. vital parameters such as HR, SBP, DBP, MAP, and SPO2 recorded at baseline (T0), before induction (T1), after induction (T2), during laryngoscopy (T3 ) ,after intubation at 1min, 2min, 3min, 5min and at 10 min. Time of induction was taken as period between time of start of study drug till loss of eyelash reflex
 Conclusion: Induction time between the two study groups was statistically insignificant. (p>0.05) The fall in heart rate at post induction (T2), at 1 min, 2 min after intubation in Group P as compared to Group E was statistically significant, fall in SBP, DBP and MAP at post induction (T2), at 1 min, 2 min, 3 min and 5 min after intubation in Group P as compared to Group E was statistically significant. Pain on injection was more with propofol. However, myoclonus was more with etomidate.
Highlights
Anesthesiologists' tools for maintaining airway integrity include endotracheal intubation and laryngoscopy
60 ASA I and II patients randomly divided into two groups group P and group E of 30 each of either sex in age group of 1865 years posted for elective surgery under general anesthesia
Due to reflex sympathetic stimulation, direct laryngoscopy and endotracheal intubation typically cause a cardiovascular stress response characterized by hypertension and tachycardia
Summary
Anesthesiologists' tools for maintaining airway integrity include endotracheal intubation and laryngoscopy. Reid and Brace characterized the hemodynamic response to laryngoscopy and tracheal intubation for the first time in 1940 [2]. Due to reflex sympathetic stimulation, direct laryngoscopy and endotracheal intubation typically cause a cardiovascular stress response characterized by hypertension and tachycardia. This response is brief, lasting less than 10 minutes and occurring 30 seconds after laryngoscopy and intubation [3]. Propofol and Etomidate are popular as rapid acting inducing agents. 2,6 diisopropylphenyl, is the most popular induction agent with its characteristics of rapid and smooth induction and recovery, decreased incidence of nausea and vomiting etc. 2,6 diisopropylphenyl, is the most popular induction agent with its characteristics of rapid and smooth induction and recovery, decreased incidence of nausea and vomiting etc. while on the other side, it decreases blood pressure, cardiac output, and systemic vascular resistance [4,5] due to inhibition of sympathetic vasoconstriction and impairment of baroreceptor reflex regulatory system [6,7]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
