Comparative study of the lipid dynamics in the surface layer of porcine and human high density lipoprotein subclasses by spin labeling

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In order to obtain information on the determinants of the lipid dynamics in the high density lipoproteins (HDL), we have compared the structural properties of human HDL subclasses with porcine HDL artificially subdivided into density subfractions corresponding to those of human HDL. Four different positional isomers of spin labeled fatty acids and spin labeled androstanol experienced more restricted motion in porcine HDL than in the human HDL 2 and HDL 3 subclasses. The differences in the spin label motion could not be accounted for on the basis of the differences in the chemical composition of the lipoproteins examined. They are, however, most probably due to the specific properties of the interactions between lipids and proteins that differ among the lipoproteins.