Abstract
Background: Diabetes Mellitus is a major health problem not only in urban but also in the rural areas of Bangladesh. Regarding its treatment, a suitable drug is yet to be available which can permanently cure this disease. Over 400 traditional plants have been reported for the treatment of diabetes, but only a small number have received scientific and medical evaluation to assess their efficacy.Objective: The study was performed to compare the anti diabetic effect of Psidium guajava Linn leaves with an oral anti diabetic drug (Glibenclamide), in experimentally induced diabetic rats.Materials and method: The experiment was carried out in the department of Pharmacology & Therapeutics of Dhaka Medical College, Dhaka, Bangladesh from July 2012 to June 2013. Twenty four healthy rats of Long Evans Norwegian strain were divided into 4 groups (group A, B, C and D) comprising 6 rats in each. Group A (normal control) received standard rat food for 14 days. Diabetes was induced by administration of Alloxan 120 mg/kg/body weight in group B, C and D. Group B (diabetic control group) was given standard rat food. Group C and D was treated with ethanol extract of Psidium guajava leaves 100 mg/kg body weight and Glibenclamide 1.5 mg/kg/day orally respectively. Total duration of the experiment was 15 days.Results: Administration of ethanol extract of Psidium guajava leaves in group C and Glibenclamide in group D produced a significant reduction (p<0.001) in blood glucose level as compared to group B (diabetic control group).Conclusion: Ethanol extract of Psidium guajava leaves can be considered as a potential anti diabetic agent like Glibenclamide but it requires further investigations.Delta Med Col J. Jan 2017 5(1): 9-14
Highlights
A days type 2 DM is one of the major public health concerns in both developing and developed countries in Asian-Pacific region
This experimental study has been performed in the department of Pharmacology & Therapeutics at Dhaka medical college, Dhaka, Bangladesh from July 2012 to June 2013
A total number of 24 healthy rats of Long Evans Norwegian strain weighing between 140-150 gm and age between 8-10 weeks which were purchased from Bangladesh Centre for Scientific and Industrial Research (BCSIR) Lab were used for the present study
Summary
A days type 2 DM is one of the major public health concerns in both developing and developed countries in Asian-Pacific region It has become epidemic in a number of countries, in newly industrialized nations. 3. Assistant Professor, Dept.of Pharmacology and Therapeutics, Ibrahim Medical College, Dhaka, Bangladesh. Of Pharmacology and Therapeutics, Delta Medical College, Dhaka, Bangladesh. Of Pharmacology and Therapeutics, Uttara Adhunic Medical College, Dhaka, Bangladesh. Group C and D was treated with ethanol extract of Psidium guajava leaves 100 mg/kg body weight and Glibenclamide 1.5 mg/kg/day orally respectively. Results: Administration of ethanol extract of Psidium guajava leaves in group C and Glibenclamide in group D produced a significant reduction (p
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