COMPARATIVE STUDY OF STANDARD COAGULATION PROFILE IN NON-DIALYZED AND POST-DIALYZED PATIENTS SUFFERING FROM CHRONIC KIDNEY DISEASE.

Abstract

Aims and Objectives: This comparative cross sectional study assessed whether there was any subtle change in the standard coagulation profile of chronic kidney disease (CKD) patients who needed no dialysis or who were dialysis candidates but had not yet started dialysis. Aim of this study was to find out any correlation between patients’ coagulation parameters and their degree of uremia. Materials and Methods: A total 30 CKD patients were carefully selected and assigned to three groups after excluding patients who were predisposed to bleeding diathesis. Group A—10 CKD patients on the verge of hemodialysis (HD); Group B—10 CKD patients who were clinically and biochemically stable and on renal replacement therapy in the form of HD; and Group C—10 CKD patients who were in the early stages of standard medical treatment. A coagulation profile study was done for all three groups using nonparametric statistical analysis. Results and Discussion: Significant thrombocytopenia and prolongation of prothrombin time (PT) were present in (Group A), whereas no significant coagulation abnormality was noted in the other two groups. A significant correlation was found between uremia (creatinine clearance) and platelet count, P time, and APTT in Group B and Group C patients and with bleeding time in patients stable with conservative management (Group C). Conclusion: The study shows coagulation parameters are progressively affected with the progress of renal disease and that dialysis has an important impact on coagulopathy in CKD.  But the coagulation parameters showed no statistically significant correlation with degree of uremia