Comparative Study Of Resistance And Aerobic Exercise In Pre-diabetes: An Rct

Abstract

PURPOSE: Although the benefit of aerobic exercise in IGR is proven, the impact of resistance exercise on IGR is still unclear. Therefore, the differences between aerobic and resistance exercise on IGR was analyzed to provide a theoretical and practical basis for DM prevention and IGR management. METHODS: Single-blind RCT. IGR participants were divided into 3 groups randomly: aerobic exercise (A, n= 26), resistance exercise (R, n= 23), and control (C, n=21). The effect of aerobic and resistance exercise on IGR was analyzed and the relationship with obesity was investigated after 12-weeks intervention. RESULTS: (1) FPG in groups A and R was decreased significantly by 6.17% and 4.81%, and OGTT 2h PG was also decreased significantly by 20.39% and 16.50%. 69.2% in group A showed a decrease in blood glucose level to normal value with a significant difference compared with group C. (2) HOMA2-IR in groups A and R was significantly decreased by 8.34% and 18.31%, with a significant difference compared with group C. 3) A significant decrease of BMI (3.1±3.2 kg/m2, showed a moderately positive correlation with the decreased FPG) and waist (3.1±2.7 cm) was found in group A with a significant difference compared with group C. BMI(1.1±2.9 kg/m2) and waist(1.5±3.8 cm) also decreased significantly in group R, but no significant difference between groups. The change of body composition showed in figure 1. CONCLUSION: (1) Both resistance and aerobic exercise lowered blood glucose and decreased blood glucose to normal level in a large percentage of IGR. (2) Both aerobic and resistance exercise improved IR in IGR. The effect of resistance exercise on IR improvement was superior to that of aerobic exercise. (3) Aerobic exercise lowered weight and waist significantly in IGR, and decreased blood glucose through weight loss. But the improvement of IR by both aerobic and resistance exercise might not be related to the control of obesity. Supported by SGA China (2014B007), Sun Yat-sen University (1709089).