Abstract
Reactive oxygen species are widely considered to be a causal factor of osteoporosis. Bioceramics have been used experimentally and clinically for filling bone defect. This study aims to characterize the oxidative stress biomarker and the antioxidant enzyme profiles during bone regeneration. Wistar rats were divided into: control group (T) ovariectomised (OVX), implanted tissue with porous and Zinc doped bioactive glass (PG) and implanted with Strontium-doped bioactive glass (BG-Sr). Grafted bone tissues were removed to measure malondialdehyde (MDA) concentration, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase activities (GPx). Our results showed that 60 days after surgery, BG-Sr groups presented a higher concentration of MDA as compared to that of PG group. However, the SOD, CAT and GPx in PG group showed higher activities when compared with those of BG-Sr group. These results suggest that 60-day period was sufficient to re-establish oxidant-antioxidant balance accompanied by bone repair.
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