Abstract

Different bioactive glass systems have been prepared by sol-gel. However, the production of Na2O-containing bioactive glasses by sol–gel methods has proved to be difficult as the sodium nitrate used in the preparation could be lost from the glass structure during filtration and washing. The aim of this study was to prepare the quaternary system 46S6 of bioactive glass by modified sol-gel techniques with a decrease in the time of gelation. In addition, compare the behaviour of the prepared sol-gel bioactive glass system by its corresponding prepared by melting. The obtained glasses were characterized by using several physicochemical techniques; XRD, FTIR, TEM and SEM beside the effect of the glass particles on the viability of osteoblast like cells (Saos-2). Results show that nanopowders 40-60 nm of 46S6 glass system had been prepared by modified sol-gel (acid-base reaction) method at 600°C in just three days at 600°C. Cell viability by MTT assay confirmed the effectiveness of the prepared nanobioactive glass.

Highlights

  • Among the production methods of bioactive materials stands out the sol-gel processing

  • The particle size of the traditional sol–gel-derived bioactive glasses was bigger than 1 μm [5] because of the long gelation and ageing time [4,5]

  • Comparing the behaviour of the prepared bioactive glass system by sol-gel named (SG-B) by its corresponding system prepared by melting technique named (MB) by means of XRF, XRD, FTIR, TEM and SEM before and after immersion in simulated body fluid (SBF)

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Summary

Introduction

Among the production methods of bioactive materials stands out the sol-gel processing. The objective of this study was to prepare the quaternary system 46S6 of bioactive glass by modified sol- gel techniques in shorter time as previously mentioned. Comparing the behaviour of the prepared bioactive glass system by sol-gel named (SG-B) by its corresponding system prepared by melting technique named (MB) by means of XRF, XRD, FTIR, TEM and SEM before and after immersion in simulated body fluid (SBF).

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