Comparative Study of Lipid Profile among Stroke Patients with Gender Variations: A Study in Mymensingh Medical College Hospital, Mymensingh, Bangladesh

Abstract

Introduction: Stroke is defined according to WHO as rapidly developing clinical signs of focal disturbance of cerebral functions with symptoms lasting for 24hrs or longer or leading to death, with no apparent cause other than vascular origin. More than 2400 years ago the father of modern medicine Hippocrates recognized and described stroke as sudden onset of paralysis. In Bangladesh day by day increase in stoke patients. Objective: This study was aimed to find out the association of one common risk factor of cardiovascular complication risk factor namely lipids level in stroke patient. And the main course of the study is to find the lipid level variations among both genders of stroke population. Materials and Methods: The stroke patients admitted in the Department of Neurology, Mymensingh Medical College Hospital, Mymensingh, Bangladeshduring the period of January 2019 to June 2019 included in this study. Patients with diagnosis of stroke comprising 50 consecutive patients of both the genders of age group around 21-60yrs were included in the study while patients on lipid lowering therapy were excluded from study. A serum sample after 12 hours of overnight fasting was taken on the both groups of patients. Results: Total serum cholesterol was high in female stroke patient’s 210±32.92 mg/dl when compared to male stroke patient’s 190±25.82 mg/dl which is statistically significant. Total triglycerides were increased in females stroke patients because of high body mass index when compared to male stroke patients was around 213±23.92, 197±58.43 mg/which is statistically significant. HDL-cholesterol level were very low in female stroke patients when compared to male stroke patients this is statistically more significant. The values were around 23.72±12.06, 37.43±7.18 mg/dl. LDL cholesterol is the direct marker of large vessel obstruction. LDL cholesterol level was found to be more in female stroke patients when compared to male stroke patients. The values are 141.81±31.89, 123.92±33.73 mg/dl. VLDL-cholesterol was high in female stroke patients when compared to male stroke patients which are statistically significant the values are 44.93±8.75, 37.83±9.33 mg/dl. Conclusion: Different environmental factors, genetic influences, and aging are playing a wide role in the prevalence of stroke among the old age group. Dyslipidaemia is a major risk factor for coronary heart disease, and atherosclerosis. In our study female patients had an increase in lipid level when compared to males.