Abstract
Background: Mosquito bite reaction is a common skin disease. Topical steroids and oral antihistamines are the conventional treatment. However, the side effects from prolonged use of topical steroids are the limitation of the treatment. Recently, herbal extracts are emerging interest for an alternative anti-inflammatory dermatoses therapy. Objective: To assess the effectiveness of herbal extracted gel containing, Perilla frutescens, Portulaca oleracea, Ipomoea pescaprae, Aloe vera, Centella asiatica and Broussonetia papyrifera in comparing with 1% hydrocortisone (HC) gel. Material and Methods: An experimental study was conducted on 50 mosquito bite hypersensitive volunteers (15 - 19 years old) with double-blinded split randomized control method. After the volunteers were exposed for one bite on their arms by a non-infectious mosquito, Aedes albopictus, the drugs were applied twice daily. The diameter of lesion, pruritus analog score, erythema and melanin index were measured at 2, 6, 24 hours and 2, 3, 4 weeks. The volunteers “self-satisfaction” and side effects were recorded. Results: The mean age was 17.42 ± 1.14 years old. The diameter of lesion, pruritus analog score, erythema and melanin index were decreased on both sides at each visit with significant difference (p 0.05). The post-inflammatory hyperpigmentation rate of 1% HC and herbal gel was 64% and 54% respectively without significant difference (p = 0.267). Conclusion: The herbal gel was as effective as 1% HC for the treatment of acute and late reaction of mosquito bite reaction in adolescent. It may be used as the alternative treatment for mosquito bite reaction.
Highlights
Mosquito bite reaction is very common in children especially who live in tropical countries [1,2].The clinical manifestation is starting with an immediate type I hypersensitivity response which is presented as wheals and flares within 20 minutes
The diameter of the papules and plaques were reduced after the treatments with 1% hydrocortisone gel and herbal extracted gel
There was no significant difference between the two agents (p = 0.481). The results of this experimental study showed that the combination of herbal extracts could improve the mosquito bite reaction both subjective measurements, objective assessments, and volunteer’s self satisfactions evaluation with statistically significant difference from the base line
Summary
Mosquito bite reaction is very common in children especially who live in tropical countries [1,2].The clinical manifestation is starting with an immediate type I hypersensitivity response which is presented as wheals and flares within 20 minutes. It is followed by the delayed type IV hypersensitivity reaction which is presented as itching, burning, erythematous, edematous papules, occured approximately 24 hours later and may last for several days. Conclusion: The herbal gel was as effective as 1% HC for the treatment of acute and late reaction of mosquito bite reaction in adolescent. It may be used as the alternative treatment for mosquito bite reaction
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