Abstract
The effect of Perilla frutescens L. leaves extract (PFLE) on melanogenesis regulation in B16F10 cells was investigated. The extract had a significant inhibitory effect on melanogenesis in a dose-dependent manner without cytotoxicity at concentrations between 2.5 and 10 μg/mL. The PFLE was formulated as an underarm serum (PL serum) and evaluated for skin irritation and its skin whitening efficacy on 30 Thai women twice daily for 4 weeks. Changes in skin melanin and erythema index, L* a* values were studied. A gradual decrease in melanin index from 37.94±0.66 to 35.90±0.64 (5.38%), and a significant decrease in erythema index from 11.32±0.79 to 10.21±0.11 (9.80%) could be observed during a 4-week period. Therefore, the efficacy of PL serum in improving skin was demonstrated by a significant decrease in melanin and erythema index compared with initial values and skin tone was improved without skin irritation. Extract from Perilla frutescens L. leaves can be used as a novel whitening cosmeceutical ingredient.
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