Comparative study of gated myocardial perfusion imaging using 99Tcm-tetrofosmin and 99Tcm-sestamibi

Abstract

Objective Tocompare the results of 99Tcm-tetrofosmin (TF) and 99Tcm-MIBI G-MPI in evaluating left ventricular myocardial perfusion and other functional parameters.Methods TF and MIBI were both labeled by 99Tcm and the radiochemical purities were tested.During December 2011 to May 2012,112 patients who had examinations of CAG and echocardiograph in one week after G-MPI were divided into 99Tcm-TF group (47 patients) and 99Tcm-MIBI group (65 patients) by simple random sampling.Patients who suffered from severe arrhythmia,clinically suspicious of mycarditis or cardiomyopathy were excluded.The research was approvel by the ethics committee,and all patients signed informed consents.One-day 99Tcm-TF G-MPI and two-day 99Tcm-MIBI G-MPI were performed.The left ventricular functional parameters were acquired automatically by Cedars quantitative gated SPECT (QGS) software,including LVEF,EDV,ESV,peak filling rate (PFR),peak ejection rate (PER) and phase standard difference (SD).The data were analyzed using x2 test,two-sample t test,paired t test and linear correlation analysis by SPSS 17.0.Results The radiochemical purities of 99Tcm-TF and 99Tcm-MIBI were (97.5±0.4) ％ and (99.1±0.2) ％ respectively.The coincidence rates of 99Tcm-TF and 99Tcm-MIBI G-MPI with CAG were 88.9％ (40/45) and 90.5％ (57/63),respectively.There was no significant difference between G-MPI results of the two agents (x2 =0.389,P＞0.05).There was also no significant difference between left ventricular functional parameters of the two agents (LVEF:(62.60±13.56)％ vs (60.52±7.08)％,t=0.940; EDV:(103.3±17.29) ml vs (98.52±19.37) ml,t=1.348; ESV:(41.73±12.69) ml vs (46.05±10.81) ml,t=0.851; PER:(2.73±0.67)EDV/s vs (2.61±1.04) EDV/s,t=0.725; PFR:(2.13±0.80) EDV/s vs (2.07±1.09) EDV/s,t=0.339;phase SD:(5.58±4.16)° vs (5.97±4.64)°,t=0.450; all P＞0.05).There was no significant difference between left ventricular functional parameters by G-MPI and UCG (LVEF:(61.39± 10.28) ％ vs (62.13±8.51) ％,t=0.991 ; EDV:(100.50±18.61) ml vs (101.70±18.34) ml,t=1.806; ESV:(44.25±11.77) ml vs (43.94±11.28) ml,t=0.658; all P＞0.05).LVEF,EDV,ESV by G-MPI correlated with the results of UCG (r=0.673,0.710,0.452,all P＜0.05).Conclusion 99Tcm-TF can also be used as a G-MPI agent to evaluate left ventricular myocardial perfusion and other functional parameters. Key words: Myocardial diseases ; Tomography, emission-computed, single-photon; Technetium ; Tetrofosmin ; MIBI