Comparative study of elastography and histopathology findings of breast lump at a tertiary hospital

Abstract

ackground: Cancer breast has emerged as leading site of cancer in most urban populations of India. Breast sono- elastography is a non-invasive imaging technique which provides information on breast lesions. In present study we compared elastography and histopathology findings of breast lump and diagnostic accuracy of elastography. Material and Methods: Present study was a prospective observational study conducted in females patients, sonographically visible solid breast lesions, measuring less than 3 cm, classified as BI‑RADS 3 and 4. Results: During study period 126 female patients underwent USG elastography, followed by biopsy/surgery and histopathology reports were available. As per histopathology, 52 (41.72 %) were benign while rest 74 (58.73 %) were malignant. Age, BIRADS, Elastography Score and Strain ratio were significantly higher in malignant cases as compared to benign cases and difference was statistically significant (p<0.001). According to Histopathological diagnosis, among benign lesions majority were fibroadenoma (77.03%) others were fibrocystic disease (9.46%), benign fibroepithelial lesion (6.76%), abscess (5.41%) and sclerosing adenosis (1.35%). while, among malignant cases majority were invasive ductal carcinoma (67.31%) followed by invasive mucinous carcinoma (13.46%), invasive poorly differentiated carcinoma (7.69%), ILC (5.77%), medullary ca (1.92%), papillary ca (1.92%) and phylloids (1.92%), Excellent scores were noted with combination of Ultrasound Score + Elastography Score + Strain Ratio as sensitivity, specificity, diagnostic accuracy, NPV, and PPV of 96.00 %, 96.05 %, 96.03 %, 94.12 % and 97.33 % respectively. Conclusion: Ultrasound elastography combined with strain elastography and ultrasound score have high sensitivity, specificity, and diagnostic accuracy in differentiating benign and malignant breast masses.