Abstract
Objective To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells (BM-MSCs) or adenovirus 5-hepatocyte growth factor (Ad 5-HGF) via non-infarct-related artery injection in swine myocardial infarction models. Methods BM-MSCs were obtained from swine bone marrow and expanded in vitro to a purity of >50%. A myocardial infarction (MI) was created by ligating the distal left anterior descending artery in swine. Either BM-MSCs (5 × 10 6/ml) or Ad 5-HGF (4 × 10 9 pfu) were transfused via the right coronary artery (non-infarcted artery) four weeks after MI. Gate-controled cardiac perfusion imaging was performed at the end of four and seven weeks after LAD ligation, to evaluate heart function and cardiac perfusion. Morphologic and histologic characteristics of the hearts were also studied. Results (1)The gate-controlled cardiac perfusion imaging showed that the improvement in LVEF was greater in both treatment groups than in control group at the 4th weeks. (2)In both treatment groups, capillary density was significantly higher than that of control group ( P < 0.05). Conclusion BM-MSCs or Ad 5-HGF transplantation via non-infarcted artery administration can stimulate angiogenesis and improve heart function, but there was no difference in therapeutic efficacy between BM-MSCs and Ad 5-HGF.
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