Abstract
Aim: The purpose of this study was to compare the dosimetric results of the techniques (3D-Brachytherapy and intensity-modulated radiotherapy IMRT) in patients with locally advanced cervical carcinoma (LACC). Method: There are 15 patients with locally advanced cervical carcinoma (LACC), after the completion of external beam radiotherapy (EBRT) for the whole pelvic irradiation 45 Gy/25 fractions, followed by 3D-Brachytherapy 24 Gy per weekly fractions and 36 Gy of IMRT per 18 fractions. Coverage of targets volume and doses received by normal tissue were compared in two techniques. Method: 15 patients of LACC treated with 3D-Brachytherapy were selected for this study. IMRT plans were also created for all the patients. 3D-Brachytherapy and IMRT plans were compared on the basis of target volume coverage, dose to Organs at risk (OAR’s), homogeneity index (HI) and conformity index (CI). Results: The results showed that D90% of HRCTV in the 3D-Brachytherapy was covered more than D90% of PTV in the IMRT of prescribed dose, the D2CC and the V60Gy values of Bladder and rectum were significantly lower than in 3D-Brachytherapy. The HI and CI in 3D-Brachytherapy were found better than IMRT. Conclusion: 3D-Brachytherapy significantly reduced the irradiated volume of OAR’s and improved dose coverage in tumor volume compared to that by IMRT.
Highlights
Cervical cancer is the fourth most frequent cancer in women with an estimated 570,000 new cases in 2018, representing 6.6% of female cancers
Aim: The purpose of this study was to compare the dosimetric results of the techniques (3D-Brachytherapy and intensity-modulated radiotherapy Intensity-Modulated Radiation Therapy (IMRT)) in patients with locally advanced cervical carcinoma (LACC)
IMRT plans were created for all the patients. 3D-Brachytherapy and IMRT plans were compared on the basis of target volume coverage, dose to Organs at risk (OAR’s), homogeneity index (HI) and conformity index (CI)
Summary
Cervical cancer is the fourth most frequent cancer in women with an estimated 570,000 new cases in 2018, representing 6.6% of female cancers. About 90% of deaths from cervical cancer occurred in low- and middle-income countries [1]. The human papillomavirus (HPV) is the main cause of cervical cancer. HPV is a common virus that is passed from one person to another during sex. Most sexually active people will have HPV at some point in their lives, but few women will get cervical cancer [2]. Brachytherapy is a method of treatment in which sealed radioactive sources are used to deliver radiation at a short distance by interstitial, intracavitary, or surface applications; a high radiation dose can be delivered locally to the tumour with rapid dose fall off in the surrounding normal tissue [3] [4]
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