Comparative study of bone microarchitactural structure after porous bioglass and Strontium doped bioactive glass bone graft in Wistar rat model

Abstract

Osteoporosis is an important systemic skeletal disease, characterized by reduction in bone mass and disruption of the microarchitectural structure of bone tissue, resulting in loss of mechanical strength and increased risk of fracture. Wistar rats were divided into four groups: the group (I) was used as negative control (T), after ovariectomy, groups II, III, IV and V were used respectively as positive control (OVX), implanted tissue with Strontium doped bioactive glass (BG-Sr) (OVX-BG-Sr) implanted tissue with Porous bioactive glass (OVX-PG) . The histomorphometric analysis demonstrated that BV/TV, N. Ob was significantly higher in PG treated rats groups than those of BG-Sr groups. However, the (Oc.S/ BS) parameter was significantly decreased in PG groups when compared with that of BG-Sr treated rats. On the other hand, the MS/BS had not significantly decreased in the PG treated rats groups when compared with that of BG-Sr rat groups. After 60 days of implantation, the microarchitecture in PG bone were more ameliorated then that of BG-Sr bone. Both of PG and BG-sr groups were more amilorated than that of OVX groups. Therefore, our findings suggested that both PG and BG-Sr might have promising applications in osteoporotic diseases.