Abstract
Artemisia herba alba asso, peel and leaves of Citrus aurantium grown in the western Algerian city (Mascara) were subjected to hydrodistillation by Clevenger dispositive. The essential oils obtained were analyzed by gas chromatography coupled to mass spectrometry and used for the study of the antifungal activity against five clinical strains of Candida albicans. The results of chemical analysis revealed 40 constituents in Artemisia essential oil, where the major components were camphor (34.89%) and chrysantenone (19.60%). While, the main component of peel and leaves of Citrus essential oils was the lineal (42.33%, 60.62%) respectively. The lowest minimum inhibitory concentration value was found in the case of Artemisia essential oil (1.95l/ml) against the (S3) Candida albicans strain. The experimental results confirmed that these extracts are marked by significant anti-fungal activity, which can be used as alternative drugs against candidiasis.
Highlights
Plants have been a major source of therapeutic agents since ancient time, these resources and their derivatives are looked as an important commodity item of international trade and commerce (Kurian and Sankar, 2007)
The essential oils obtained were analyzed by gas chromatography coupled to mass spectrometry and used for the study of the antifungal activity against five clinical strains of Candida albicans
The purpose of this study was to investigate the chemical composition of three essential oils by the gas chromatography coupled to mass spectrometry (GC/MS) and to improve their antifungal activities by disc diffusion method on Muller–Hinton agar
Summary
Plants have been a major source of therapeutic agents since ancient time, these resources and their derivatives are looked as an important commodity item of international trade and commerce (Kurian and Sankar, 2007). The Artemisia is one of the largest genera of the family of Asteraceae, bushy subshrub widespread in the highlands, and the steppe zones It is characteristic of the deserts of the Middle East and the North Africa. While the second species was Citrus aurantium (bitter orange) belongs to the family of Rutaceae. It is a dark green tree with fragrant white flowers and orange fruit. It is not edible because it tastes bitter (10 m high) (Anonyme, 2001). The purpose of this study was to investigate the chemical composition of three essential oils by the gas chromatography coupled to mass spectrometry (GC/MS) and to improve their antifungal activities by disc diffusion method on Muller–Hinton agar
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