Abstract
Glimepiride is an antidiabetic agent used for lowering blood glucose levels. It induces the activity of peroxisome proliferator-activated receptor-gamma (PPAR gamma). It lowers blood glucose levels by binding to ATP-sensitive potassium channel receptors on the surface of pancreatic cells. The purpose of this study was to perform a comparative analysis of different physicochemical parameters (weight variation, hardness, thickness, friability, disintegration time, and dissolution time) of 3 different commercially available brands of glimepiride in the market. Statistical analysis revealed minor variations in the results. It was found that GETRYL showed the highest % dissolution among all the 3 brands whereas AMARYL took the least time to disintegrate. According to the results of the friability test, Diabold shows the highest stability in the friabilator. However, all 3 brands complied with the official pharmacopoeial limits. The quality of the drug largely influences its therapeutic activity. Hence, owing to the similar physicochemical profile, all the 3 brands can be interchangeably used.
Highlights
Excessive levels of sugar in the blood leads to a disease called Diabetes Mellitus [1]
The utilization of glucose is mediated by the hormone “insulin” produced by the beta cells of the pancreas
If the body is unable to secrete insulin or insulin is not properly utilizing glucose to produce energy, the glucose starts to accumulate in the blood and eventually manifests as Diabetes Mellitus
Summary
Excessive levels of sugar in the blood leads to a disease called Diabetes Mellitus [1]. In a disease-free state, energy to the body is provided by utilizing glucose which is generally achieved from food intake [2]. The utilization of glucose is mediated by the hormone “insulin” produced by the beta cells of the pancreas. Insulin is released in response to the elevated levels of glucose in the body. If the body is unable to secrete insulin or insulin is not properly utilizing glucose to produce energy, the glucose starts to accumulate in the blood and eventually manifests as Diabetes Mellitus. Drugs that mimic the secretion or improve the uptake of insulin are the preferred choice for type II Diabetes, while, insulin and its analogs are the preferred therapeutic option in type I.
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