Comparative study in photodynamic therapy using the same photosensitizer in tissue repair after second-degree burns in an experimental model

Abstract

Photodynamic therapy is a therapeutic resource used to treat different pathologies such as neoplasias and wound healing. It consists of a light coupled to a photosensitizer that is used to react with oxygen and forming reactive oxygen species that reach target cells. This study aimed to evaluate the effect of PDT on the healing of second-degree burns. The study used 45 Wistar Rattus Norvegicus divided into three groups, two with lesions and treatment and one with lesions and without treatment (control group). Group PDT6 was lesioned and treated with 630- nm LED PDT and group PDT9 was lesioned and treated with 945- nm LED PDT. The results suggest collagen deposition and development of cellular structures of normal tissue in the treated groups compared to the control groups. It was concluded that the PDT treatment induced enhanced tissue repair in the treated groups; the best results were observed using the 630- nm LED.